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Efficacy of Rivastigmine in Dementia with Lewy Bodies: a Randomised, Double-blind, Placebo-controlled International Study
Lancet, 356:2031-2036,2024, McKeith,I.,et al, 2000
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Article Abstract
Patients taking rivastigmine were significantly less apathetic and anxious, and had fewer delusions and hallucinations while on treatment than controls. Almost twice as many patients on rivastigmine (37, 63%), than on placebo (18, 30%), sho wed at least a 30% improvement from baseline. Rivastigmine 6-12 mg daily produces statistically and clinically significant behavioural effects in patients with Lewy-body dementia, and seems safe and well tolerated if titrated individually.
 
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anticholinesterase
behavior
Lewy body disease,diffuse
rivastigmine
treatment of neurologic disorder

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